Newborn Calf Serum is obtained from calves approximately two weeks of age. Newborn calf serum contains higher levels of immunoglobulins and total protein than fetal bovine serum (FBS), making it a cost-effective and functionally suitable alternative to FBS in certain applications.
Serum is commonly added to cell culture media to support cell growth and serves multiple essential functions: it provides macromolecular proteins and low-molecular-weight nutrients—including amino acids, carbohydrates, and vitamins; enhances the buffering capacity of the medium; binds or neutralizes toxic substances; reduces oxidative stress and apoptosis; and supplies growth-promoting factors that aid cellular adaptation to the culture environment.
Heat inactivation of serum is performed by incubating it at 56 °C for 30 minutes. This process inactivates complement proteins and prevents complement-mediated cell lysis during antibody-based assays.
Newborn calf serum provides many of the same nutrients as fetal bovine serum (FBS). Protein and immunoglobulin levels are slightly higher in Newborn calf serum, whereas growth factor concentrations are lower—making it suitable for culturing robust cell lines or cells with low culture requirements.
Manufactured under ISO 13485 QMS and in compliance with applicable cGMP guidelines.