N-deacetyl-N-methylcolchicine (demecolcine, colcemid) is related to colchicine but it is less toxic. Colcemid depolymerizes microtubules, limits microtubule formation, and inactivates the spindle fiber mechanism during metaphase.

Product Features:

• Higher stability and lower cytotoxicity;
• Colcemid binds to DNA, stabilizing chromosomal structure and preserving morphological integrity;
• Enhanced cell membrane permeability facilitates observation and analysis.

In clinical chromosomal analysis, Colcemid exhibits lower cytotoxicity compared to colchicine.
As a microtubule polymerization inhibitor, it arrests mitosis at metaphase by disrupting spindle formation, thereby yielding abundant metaphase cells for karyotyping.
The optimized formulation of Colcemid enhances cytogenetic preparation efficiency and quality, enabling extended chromosomal spreading for improved visualization and analytical precision.