RepSox
Product Description
RepSox is a potent and selective inhibitor of the TGF-β type 1 receptor (TGFβRI)/ALK5 that exhibits cell permeability and specifically inhibits ALK5 autophosphorylation with IC50 of 4 nM. When used in conjunction with CHIR99021 (Cat. No. SM-0001-0010), LDN193189 (Cat. No. SM-0005-0010), and Y27632 (Cat. No. SM-0013-0010), among others, RepSox aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.). RepSox has also been shown to contribute to the reprogramming of mouse embryonic fibroblasts to iPSCs (Subramanyam, et al.), in addition to the induction of human fibroblasts into neuronal cells for research on Alzheimer’s disease (Hu, et al).
Product Synonyms:
ALK5 inhibitor II, ALK5 Inhibitor, ALK5i, E-616452, SJN2511
Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.
产品官网链接:https://www.bioind.com/worldwide/repsox/
想了解更多种类的小分子,请点击官网:https://www.bioind.com/worldwide/products/stem-cell-research/small-molecules/
Copy right 2012 by Shanghai XP Biomed Ltd. All Rights Reserved
沪 ICP备12039761号-1 沪ICP备12039761号-2 沪ICP备12039761号-3 沪ICP备13002267号-1